Network pharmacology and in vitro experimental verification to reveal the mechanism of Astragaloside IV against kidney ischemia-reperfusion injury

Network pharmacology and in vitro experimental verification to reveal the mechanism of Astragaloside IV against kidney ischemia-reperfusion injury

Ischemic acute kidney injury (AKI) is a prevalent disorder among hospitalized patients worldwide. Astragaloside IV (AS-IV) has been shown to protect against ischemic AKI. However, the specific effects and mechanisms of AS-IV on alleviating kidney ischemia-reperfusion (I/R) injury remain unclear. The...

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Bibliographic Details
Main Authors: Yan Guo, Jinfu Wang, Yanjie Hua, Mengya Jiang, Wanyue Xu, Yanpeng Shi, Jiehong Yang, Haitong Wan, Ruchun Yang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Heliyon
Subjects:
Astragaloside IV
Kidney ischemia-reperfusion injury
Ferroptosis
Network pharmacology
Molecular docking
Molecular dynamics simulations
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023089193

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http://www.sciencedirect.com/science/article/pii/S2405844023089193

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