Long-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects

Long-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects

Abstract Parkinson’s disease (PD) is characterized by dopaminergic neurodegeneration in nigrostriatal and cortical brain regions associated with pathogenic α-synuclein (αSyn) aggregate/oligomer accumulation. LRRK2 hyperactivity is a disease-modifying therapeutic target in PD. However, LRRK2 inhibiti...

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Bibliographic Details
Main Authors: Philip Wing-Lok Ho, Eunice Eun-Seo Chang, Chi-Ting Leung, Huifang Liu, Yasine Malki, Shirley Yin-Yu Pang, Zoe Yuen-Kiu Choi, Yingmin Liang, Weng Seng Lai, Yuefei Ruan, Kenneth Mei-Yee Leung, Susan Yung, Judith Choi-Wo Mak, Michelle Hiu-Wai Kung, David B. Ramsden, Shu-Leong Ho
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-022-00386-9

Internet

https://doi.org/10.1038/s41531-022-00386-9

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