Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity.

Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity.

The recruitment kinetics of double-strand break (DSB) signaling and repair proteins Mdc1, 53BP1 and Rad52 into radiation-induced foci was studied by live-cell fluorescence microscopy after ion microirradiation. To investigate the influence of damage density and complexity on recruitment kinetics, wh...

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Bibliographic Details
Main Authors: Volker Hable, Guido A Drexler, Tino Brüning, Christian Burgdorf, Christoph Greubel, Anja Derer, Judith Seel, Hilmar Strickfaden, Thomas Cremer, Anna A Friedl, Günther Dollinger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3408406?pdf=render

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http://europepmc.org/articles/PMC3408406?pdf=render

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