Kynurenic Acid Analog Attenuates the Production of Tumor Necrosis Factor-α, Calgranulins (S100A 8/9 and S100A 12), and the Secretion of HNP1–3 and Stimulates the Production of Tumor Necrosis Factor-Stimulated Gene-6 in Whole Blood Cultures of Patients With Rheumatoid Arthritis

Kynurenic Acid Analog Attenuates the Production of Tumor Necrosis Factor-α, Calgranulins (S100A 8/9 and S100A 12), and the Secretion of HNP1–3 and Stimulates the Production of Tumor Necrosis Factor-Stimulated Gene-6 in Whole Blood Cultures of Patients With Rheumatoid Arthritis

Objectives: Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease with complex pathogenesis involving a variety of immunological events. Recently, it has been suggested that kynurenic acid (KYNA) might be a potential regulator of inflammatory processes in arthritis. KYNA has a definitiv...

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Bibliographic Details
Main Authors: Attila Balog, Borisz Varga, Ferenc Fülöp, Ildikó Lantos, Gergely Toldi, László Vécsei, Yvette Mándi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
kynurenine
TNF-α
TSG-6
TNFα-stimulated gene-6
calgranulins
HNP1–3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.632513/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.632513/full

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