A kinase-dependent feedforward loop affects CREBB stability and long term memory formation

A kinase-dependent feedforward loop affects CREBB stability and long term memory formation

In Drosophila, long-term memory (LTM) requires the cAMP-dependent transcription factor CREBB, expressed in the mushroom bodies (MB) and phosphorylated by PKA. To identify other kinases required for memory formation, we integrated Trojan exons encoding T2A-GAL4 into genes encoding putative kinases an...

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Bibliographic Details
Main Authors: Pei-Tseng Lee, Guang Lin, Wen-Wen Lin, Fengqiu Diao, Benjamin H White, Hugo J Bellen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
Drosophila
mushroom bodies
SBK1
deGradFP
T2A-GAL4
MiMIC
Online Access:https://elifesciences.org/articles/33007

Internet

https://elifesciences.org/articles/33007

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