Measurement of Hepatic CYP3A4 and 2D6 Activity Using Radioiodine-Labeled <i>O</i>-Desmethylvenlafaxine

Measurement of Hepatic CYP3A4 and 2D6 Activity Using Radioiodine-Labeled <i>O</i>-Desmethylvenlafaxine

Drug metabolizing enzyme activity is affected by various factors such as drug–drug interactions, and a method to quantify drug metabolizing enzyme activity in real time is needed. In this study, we developed a novel radiopharmaceutical for quantitative imaging to estimate hepatic CYP3A4 and CYP2D6 a...

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Bibliographic Details
Main Authors: Asuka Mizutani, Masato Kobayashi, Riku Aibe, Yuka Muranaka, Kodai Nishi, Masanori Kitamura, Chie Suzuki, Ryuichi Nishii, Naoto Shikano, Yasuhiro Magata, Yasushi Ishida, Munetaka Kunishima, Keiichi Kawai
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
<i>O</i>-desmethylvenlafaxine
whole-body imaging
CYP3A4
CYP2D6
individualized medicine
Online Access:https://www.mdpi.com/1422-0067/23/19/11458

Internet

https://www.mdpi.com/1422-0067/23/19/11458

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