Absent in Melanoma (AIM)2 Promotes the Outcome of Islet Transplantation by Repressing Ischemia-Induced Interferon (IFN) Signaling

Absent in Melanoma (AIM)2 Promotes the Outcome of Islet Transplantation by Repressing Ischemia-Induced Interferon (IFN) Signaling

Clinical islet transplantation is limited by ischemia-induced islet cell death. Recently, it has been reported that the absent in melanoma (AIM)2 inflammasome is upregulated by ischemic cell death due to recognition of aberrant cytoplasmic self-dsDNA. However, it is unknown whether AIM2 determines t...

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Bibliographic Details
Main Authors: Selina Wrublewsky, Cedric Wilden, Caroline Bickelmann, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
AIM2
inflammasome
islet transplantation
interferon
revascularization
Online Access:https://www.mdpi.com/2073-4409/13/1/16

Internet

https://www.mdpi.com/2073-4409/13/1/16

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