Antibodies to S2 domain of SARS-CoV-2 spike protein in Moderna mRNA vaccinated subjects sustain antibody-dependent NK cell-mediated cell cytotoxicity against Omicron BA.1

Antibodies to S2 domain of SARS-CoV-2 spike protein in Moderna mRNA vaccinated subjects sustain antibody-dependent NK cell-mediated cell cytotoxicity against Omicron BA.1

Vaccination with the primary two-dose series of SARS-CoV-2 mRNA protects against infection with the ancestral strain, and limits the presentation of severe disease after re-infection by multiple variants of concern (VOC), including Omicron, despite the lack of a strong neutralizing response to these...

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Bibliographic Details
Main Authors: Corey A. Balinsky, Le Jiang, Vihasi Jani, Ying Cheng, Zhiwen Zhang, Tatyana Belinskaya, Qi Qiu, Tran Khanh Long, Megan A. Schilling, Sarah A. Jenkins, Karen S. Corson, Nicholas J. Martin, Andrew G. Letizia, Robert D. Hontz, Peifang Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
Moderna mRNA vaccine
ADCC
S2
Omicron BA.1
IgG subclass
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266829/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266829/full

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