Modified exosomal SIRPα variants alleviate white matter injury after intracerebral hemorrhage via microglia/macrophages

Modified exosomal SIRPα variants alleviate white matter injury after intracerebral hemorrhage via microglia/macrophages

Abstract Background Despite limited efficiency, modulation of microglia/macrophages has shown to attenuate neuroinflammation after intracerebral hemorrhage (ICH). In this context, we evaluated the efficacy of modified exosomal signal regulatory protein α (SIRPα) variants (SIRPα-v Exos) in microglia/...

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Bibliographic Details
Main Authors: Xinjie Gao, Heng Yang, Weiping Xiao, Jiabin Su, Yuwen Zhang, He Wang, Wei Ni, Yuxiang Gu
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2022-11-01
Series:Biomaterials Research
Subjects:
Exosome
SIRPα variant
Intracerebral hemorrhage
White matter injury
Microglia/macrophages
Online Access:https://doi.org/10.1186/s40824-022-00311-4

Internet

https://doi.org/10.1186/s40824-022-00311-4

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