Advanced Intestinal Cancers often Maintain a Multi-Ancestral Architecture.

A widely accepted paradigm in the field of cancer biology is that solid tumors are uni-ancestral being derived from a single founder and its descendants. However, data have been steadily accruing that indicate early tumors in mice and humans can have a multi-ancestral origin in which an initiated pr...

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Bibliographic Details
Main Authors: Christopher D Zahm, Joseph M Szulczewski, Alyssa A Leystra, Terrah J Paul Olson, Linda Clipson, Dawn M Albrecht, Malisa Middlebrooks, Andrew T Thliveris, Kristina A Matkowskyj, Mary Kay Washington, Michael A Newton, Kevin W Eliceiri, Richard B Halberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4769224?pdf=render