Analysis of IGH allele content in a sample group of rheumatoid arthritis patients demonstrates unrevealed population heterogeneity

Analysis of IGH allele content in a sample group of rheumatoid arthritis patients demonstrates unrevealed population heterogeneity

Immunoglobulin heavy chain (IGH) germline gene variations influence the B cell receptor repertoire, with resulting biological consequences such as shaping our response to infections and altering disease susceptibilities. However, the lack of information on polymorphism frequencies in the IGH loci at...

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Bibliographic Details
Main Authors: Uta Hardt, Martin M. Corcoran, Sanjana Narang, Vivianne Malmström, Leonid Padyukov, Gunilla B. Karlsson Hedestam
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
immunoglobulin heavy chain
germline gene variation
haplotyping
recombination signal sequence
polymorphism
rheumatoid arthritis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1073414/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1073414/full

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