Plasma Cell Alloantigen 1 and IL-10 Secretion Define Two Distinct Peritoneal B1a B Cell Subsets With Opposite Functions, PC1high Cells Being Protective and PC1low Cells Harmful for the Growing Fetus

Plasma Cell Alloantigen 1 and IL-10 Secretion Define Two Distinct Peritoneal B1a B Cell Subsets With Opposite Functions, PC1high Cells Being Protective and PC1low Cells Harmful for the Growing Fetus

B cells possess various immuno regulatory functions. However, research about their participation in tolerance induction toward the fetus is just emerging. Accumulating evidence supports the idea that B cells can play seemingly conflicting roles during pregnancy, either protecting or harming the fetu...

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Bibliographic Details
Main Authors: Anne Schumacher, Stefanie Ehrentraut, Markus Scharm, Hongsheng Wang, Roland Hartig, Herbert C. Morse, Ana Claudia Zenclussen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
B cells
B1a B cells
fetal tolerance
interleukin-10
peritoneum
plasma cell alloantigen 1
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.01045/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.01045/full

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