FK506 increases susceptibility to musculoskeletal infection in a rodent model

Abstract Background Delayed fracture healing caused by soft tissue loss can be resolved by the administration of a Th1 immunosuppressant, such as FK506. Additionally, open fractures are at high risk for infection. We hypothesized that the inclusion of an immunosuppressant to a subject at risk for a...

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Bibliographic Details
Main Authors: Stefanie M. Shiels, Preeti J. Muire, Joseph C. Wenke
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Musculoskeletal Disorders
Subjects:
Online Access:https://doi.org/10.1186/s12891-022-05667-1