Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

Abstract Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion disease and it is characterized by the presence of neuronal loss, spongiform degeneration, chronic inflammation and the accumulation of misfolded and pathogenic prion protein (PrPSc). The molecular mechanism...

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Bibliographic Details
Main Authors: Franc Llorens, Katrin Thüne, Beata Sikorska, Matthias Schmitz, Waqas Tahir, Natalia Fernández-Borges, Maria Cramm, Nadine Gotzmann, Margarita Carmona, Nathalie Streichenberger, Uwe Michel, Saima Zafar, Anna-Lena Schuetz, Ashish Rajput, Olivier Andréoletti, Stefan Bonn, Andre Fischer, Pawel P. Liberski, Juan Maria Torres, Isidre Ferrer, Inga Zerr
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Acta Neuropathologica Communications
Subjects:
Creutzfeldt-Jakob disease
Prion protein
Calpain
Cathepsin
Calcium
Ca2+
Online Access:http://link.springer.com/article/10.1186/s40478-017-0431-y

Internet

http://link.springer.com/article/10.1186/s40478-017-0431-y

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