Biosynthetic engineering of the antifungal, anti-MRSA auroramycin

Biosynthetic engineering of the antifungal, anti-MRSA auroramycin

Abstract Using an established CRISPR-Cas mediated genome editing technique for streptomycetes, we explored the combinatorial biosynthesis potential of the auroramycin biosynthetic gene cluster in Streptomyces roseosporous. Auroramycin is a potent anti-MRSA polyene macrolactam. In addition, auroramyc...

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Bibliographic Details
Main Authors: Wan Lin Yeo, Elena Heng, Lee Ling Tan, Yi Wee Lim, Kuan Chieh Ching, De-Juin Tsai, Yi Wun Jhang, Tsai-Ling Lauderdale, Kak-Shan Shia, Huimin Zhao, Ee Lui Ang, Mingzi M. Zhang, Yee Hwee Lim, Fong T. Wong
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Microbial Cell Factories
Subjects:
Combinatorial biosynthesis
Streptomyces
Polyene macrolactam
Online Access:https://doi.org/10.1186/s12934-019-1274-y

Internet

https://doi.org/10.1186/s12934-019-1274-y

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