Design, synthesis and biological evaluation of carbohydrate-based sulphonamide derivatives as topical antiglaucoma agents through selective inhibition of carbonic anhydrase II

Design, synthesis and biological evaluation of carbohydrate-based sulphonamide derivatives as topical antiglaucoma agents through selective inhibition of carbonic anhydrase II

A series of new carbohydrate-based sulphonamide derivatives were designed, synthesised by employing the so-call ‘sugar-tail’ approach. The compounds were evaluated in vitro against a panel of CAs. Compared to their parent compound p-sulfamoylbenzoic acid, these compounds showed nearly 100-fold impro...

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Bibliografische gegevens
Hoofdauteurs: Zhuang Hou, Chuanchao Li, Yichuang Liu, Miao Zhang, Yitong Wang, Zhanfang Fan, Chun Guo, Bin Lin, Yang Liu
Formaat: Artikel
Taal:English
Gepubliceerd in: Taylor & Francis Group 2020-01-01
Reeks:Journal of Enzyme Inhibition and Medicinal Chemistry
Onderwerpen:
carbonic anhydrase ii inhibitors
sugar tail
hydrophilic half
antiglaucoma
Online toegang:http://dx.doi.org/10.1080/14756366.2019.1705293

Internet

http://dx.doi.org/10.1080/14756366.2019.1705293

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