TGF-β1 derived from macrophages contributes to load-induced tendon-bone healing in the murine rotator cuff repair model by promoting chondrogenesis

TGF-β1 derived from macrophages contributes to load-induced tendon-bone healing in the murine rotator cuff repair model by promoting chondrogenesis

Aims: It has been established that mechanical stimulation benefits tendon-bone (T-B) healing, and macrophage phenotype can be regulated by mechanical cues; moreover, the interaction between macrophages and mesenchymal stem cells (MSCs) plays a fundamental role in tissue repair. This study aimed to...

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Bibliographic Details
Main Authors: Linfeng Wang, Shengcan Li, Han Xiao, Tao Zhang, Yuqian Liu, Jianzhong Hu, Daqi Xu, Hongbin Lu
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2023-03-01
Series:Bone & Joint Research
Subjects:
mechanical stimulation
tendon-bone healing
macrophage polarization
mesenchymal stem cell chondrogenesis
transforming growth factor-β1
chondrogenesis
macrophage
transforming growth factor-beta 1
rotator cuff repair
mesenchymal stem cells (mscs)
enthesis
tendons
enzyme-linked immunosorbent assay
flow cytometry
growth factor
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.123.BJR-2022-0368.R1

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.123.BJR-2022-0368.R1

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