Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine‐gingipain inhibitor COR388

Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine‐gingipain inhibitor COR388

Abstract COR388, a small‐molecule lysine‐gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease. Gingipains are produced by two species of bacteria, Porphyromonas gingivalis and Porphyromo...

Full description

Bibliographic Details
Main Authors: Shirin Arastu‐Kapur, Mai Nguyen, Debasish Raha, Florian Ermini, Ursula Haditsch, Joseph Araujo, Ines A. M. De Lannoy, Mark I. Ryder, Stephen S. Dominy, Casey Lynch, Leslie J. Holsinger
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Pharmacology Research & Perspectives
Subjects:
Alzheimer's disease
gingipain inhibitor
P. gingivalis
P. gulae
periodontal disease
Online Access:https://doi.org/10.1002/prp2.562

Internet

https://doi.org/10.1002/prp2.562

Similar Items