Nano-Sized Extracellular Vesicles Secreted from GATA-4 Modified Mesenchymal Stem Cells Promote Angiogenesis by Delivering Let-7 miRNAs

Nano-Sized Extracellular Vesicles Secreted from GATA-4 Modified Mesenchymal Stem Cells Promote Angiogenesis by Delivering Let-7 miRNAs

We demonstrated previously that extracellular vesicles (EVs) released from mesenchymal stem cells (MSCs) play a critical role in angiogenesis. Here, we examine whether this pro-angiogenic efficacy is enhanced in EVs derived from MSCs overexpressing GATA-4 (MSC<sup>GATA−4</sup>). Methods...

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Bibliographic Details
Main Authors: Min Gong, Min Wang, Jie Xu, Bin Yu, Yi-Gang Wang, Min Liu, Muhammad Ashraf, Meifeng Xu
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
extracellular vesicles
mesenchymal stem cells
GATA-4
angiogenesis
let-7
Online Access:https://www.mdpi.com/2073-4409/11/9/1573

Internet

https://www.mdpi.com/2073-4409/11/9/1573

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