Canagliflozin protects against cisplatin-induced acute kidney injury by AMPK-mediated autophagy in renal proximal tubular cells

Abstract Sodium-glucose cotransporter 2 inhibitors, which are recently introduced as glucose-lowering agents, improve cardiovascular and renal outcomes in patients with diabetes mellitus. These drugs also have beneficial effects in various kidney disease models. However, the effect of SGLT2 inhibito...

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Bibliographic Details
Main Authors: Cheol Ho Park, Bin Lee, Myeonggil Han, Woo Joong Rhee, Man Sup Kwak, Tae-Hyun Yoo, Jeon-Soo Shin
Format: Article
Language:English
Published: Nature Publishing Group 2022-01-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00801-9