Heterologous overproduction of oviedomycin by refactoring biosynthetic gene cluster and metabolic engineering of host strain Streptomyces coelicolor

Heterologous overproduction of oviedomycin by refactoring biosynthetic gene cluster and metabolic engineering of host strain Streptomyces coelicolor

Abstract Background Oviedomycin is one among several polyketides known for their potential as anticancer agents. The biosynthetic gene cluster (BGC) for oviedomycin is primarily found in Streptomyces antibioticus. However, because this BGC is usually inactive under normal laboratory conditions, it i...

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Bibliographic Details
Main Authors: Boncheol Gu, Duck Gyun Kim, Do-Kyung Kim, Minji Kim, Hyun Uk Kim, Min-Kyu Oh
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Microbial Cell Factories
Subjects:
Metabolic engineering
Oviedomycin
Refactoring
Heterologous expression
Genome-scale metabolic model
Online Access:https://doi.org/10.1186/s12934-023-02218-8

Internet

https://doi.org/10.1186/s12934-023-02218-8

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