Mitochondrial translocator protein deficiency exacerbates pathology in acute experimental ulcerative colitis

Mitochondrial translocator protein deficiency exacerbates pathology in acute experimental ulcerative colitis

In human patients and animal models of ulcerative colitis (UC), upregulation of the mitochondrial translocator protein (TSPO) in the colon is consistent with inflammation. Although the molecular function for TSPO remains unclear, it has been investigated as a therapeutic target for ameliorating UC p...

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Bibliographic Details
Main Authors: Isabel A. Jimenez, Allison P. Stilin, Kanako Morohaku, Mahmoud H. Hussein, Prasanthi P. Koganti, Vimal Selvaraj
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Physiology
Subjects:
colon
inflammation
mast cell
mitochondria
intestinal epithelium
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.896951/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.896951/full

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