GABA<sub>A</sub> Receptor β3 Subunit Mutation N328D Heterozygous Knock-in Mice Have Lennox–Gastaut Syndrome

GABA<sub>A</sub> Receptor β3 Subunit Mutation N328D Heterozygous Knock-in Mice Have Lennox–Gastaut Syndrome

Lennox–Gastaut Syndrome (LGS) is a developmental and epileptic encephalopathy (DEE) characterized by multiple seizure types, electroencephalogram (EEG) patterns, and cognitive decline. Its etiology has a prominent genetic component, including variants in <i>GABRB3</i> that encodes the GA...

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Bibliographic Details
Main Authors: Gerald Ikemefuna Nwosu, Wangzhen Shen, Kirill Zavalin, Sarah Poliquin, Karishma Randhave, Carson Flamm, Marshall Biven, Katherine Langer, Jing-Qiong Kang
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
epilepsy
knock-in mouse model
<i>GABRB3</i>
developmental epileptic encephalopathy
Online Access:https://www.mdpi.com/1422-0067/24/9/8458

Internet

https://www.mdpi.com/1422-0067/24/9/8458

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