Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress

Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress

Summary: Pancreatic islets respond to metabolic and inflammatory stress by producing hormones and other factors that induce adaptive cellular and systemic responses. Here we show that intracellular Ca2+ ([Ca2+]i) and ROS signals generated by high glucose and cytokine-induced ER stress activate calci...

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Bibliographic Details
Main Authors: Carly M. Darden, Srividya Vasu, Jordan Mattke, Yang Liu, Christopher J. Rhodes, Bashoo Naziruddin, Michael C. Lawrence
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:iScience
Subjects:
Molecular biology
Molecular interaction
Endocrinology
Diabetology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222003959

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http://www.sciencedirect.com/science/article/pii/S2589004222003959

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