Decoupling FcRn and tumor contributions to elevated immune checkpoint inhibitor clearance in cancer cachexia

Decoupling FcRn and tumor contributions to elevated immune checkpoint inhibitor clearance in cancer cachexia

High baseline clearance of immune checkpoint inhibitors (ICIs), independent of dose or systemic exposure, is associated with cachexia and poor outcomes in cancer patients. Mechanisms linking ICI clearance, cachexia and ICI therapy failure are unknown. Here, we evaluate in four murine models and acro...

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Bibliographic Details
Main Authors: Trang T. Vu, Kyeongmin Kim, Millennium Manna, Justin Thomas, Bryan C. Remaily, Emma J. Montgomery, Travis Costa, Lauren Granchie, Zhiliang Xie, Yizhen Guo, Min Chen, Alyssa Marie M. Castillo, Samuel K. Kulp, Xiaokui Mo, Sridhar Nimmagadda, Paul Gregorevic, Dwight H. Owen, Latha P. Ganesan, Thomas A. Mace, Christopher C. Coss, Mitch A. Phelps
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Pharmacological Research
Subjects:
Cachexia
Immune Checkpoint Inhibitor
Clearance
FcRn
LLC
MC38
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823004048

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http://www.sciencedirect.com/science/article/pii/S1043661823004048

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