Structure and Cancer Immunotherapy of the B7 Family Member B7x

Structure and Cancer Immunotherapy of the B7 Family Member B7x

B7x (B7-H4 or B7S1) is a member of the B7 family that can inhibit T cell function. B7x protein is absent in most normal human tissues and immune cells, but it is overexpressed in human cancers and often correlates with negative clinical outcome. The expression pattern and function of B7x suggest tha...

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Bibliographic Details
Main Authors: Hyungjun Jeon, Vladimir Vigdorovich, Sarah C. Garrett-Thomson, Murali Janakiram, Udupi A. Ramagopal, Yael M. Abadi, Jun Sik Lee, Lisa Scandiuzzi, Kim C. Ohaegbulam, Jordan M. Chinai, Ruihua Zhao, Yu Yao, Ying Mao, Joseph A. Sparano, Steven C. Almo, Xingxing Zang
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714008365

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http://www.sciencedirect.com/science/article/pii/S2211124714008365

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