Changes in dynamics upon oligomerization regulate substrate binding and allostery in amino acid kinase family members.

Changes in dynamics upon oligomerization regulate substrate binding and allostery in amino acid kinase family members.

Oligomerization is a functional requirement for many proteins. The interfacial interactions and the overall packing geometry of the individual monomers are viewed as important determinants of the thermodynamic stability and allosteric regulation of oligomers. The present study focuses on the role of...

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Bibliografiske detaljer
Main Authors:	Enrique Marcos, Ramon Crehuet, Ivet Bahar
Format:	Article
Sprog:	English
Udgivet:	Public Library of Science (PLoS) 2011-09-01
Serier:	PLoS Computational Biology
Online adgang:	http://europepmc.org/articles/PMC3182869?pdf=render

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