Changes in dynamics upon oligomerization regulate substrate binding and allostery in amino acid kinase family members.
Oligomerization is a functional requirement for many proteins. The interfacial interactions and the overall packing geometry of the individual monomers are viewed as important determinants of the thermodynamic stability and allosteric regulation of oligomers. The present study focuses on the role of...
Հիմնական հեղինակներ: | Enrique Marcos, Ramon Crehuet, Ivet Bahar |
---|---|
Ձևաչափ: | Հոդված |
Լեզու: | English |
Հրապարակվել է: |
Public Library of Science (PLoS)
2011-09-01
|
Շարք: | PLoS Computational Biology |
Առցանց հասանելիություն: | http://europepmc.org/articles/PMC3182869?pdf=render |
Նմանատիպ նյութեր
-
On the conservation of the slow conformational dynamics within the amino acid kinase family: NAGK the paradigm.
: Enrique Marcos, և այլն
Հրապարակվել է: (2010-04-01) -
Dynamic allostery in substrate binding by human thymidylate synthase
: Jeffrey P Bonin, և այլն
Հրապարակվել է: (2022-10-01) -
Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.
: Nikita Chopra, և այլն
Հրապարակվել է: (2016-03-01) -
ATPase subdomain IA is a mediator of interdomain allostery in Hsp70 molecular chaperones.
: Ignacio J General, և այլն
Հրապարակվել է: (2014-05-01) -
Computational modeling of cAMP-dependent protein kinase allostery
: Andrei Izvolski, և այլն
Հրապարակվել է: (2023-11-01)