Proteases: essential actors in processing antigens and intracellular Toll-like receptors
MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4+ T cells. However, to elicit CD4+-T cells immunity, pAPCs need an additional signal, which can be delivered b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00299/full |
| _version_ | 1811214764688277504 |
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| author | Bénédicte eManoury |
| author_facet | Bénédicte eManoury |
| author_sort | Bénédicte eManoury |
| collection | DOAJ |
| description | MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4+ T cells. However, to elicit CD4+-T cells immunity, pAPCs need an additional signal, which can be delivered by Toll-like receptors (TLRs) molecules. TLRs recognize microbial patterns and are critical in initiating immune responses. Proteases, which provide peptide ligands for the MHC class II antigenic presentation pathway, were recently shown to cleave and activate intracellular Toll-like receptors in endosomal compartments. Here, I give an overview on the individual roles of the most well studied proteases in both antigen and TLRs processing. |
| first_indexed | 2024-04-12T06:10:23Z |
| format | Article |
| id | doaj.art-2e77f79534a74676a399d84ab4fd4223 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T06:10:23Z |
| publishDate | 2013-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2e77f79534a74676a399d84ab4fd42232022-12-22T03:44:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-09-01410.3389/fimmu.2013.0029964675Proteases: essential actors in processing antigens and intracellular Toll-like receptorsBénédicte eManoury0INSERM U1013, Université Paris Descartes, Sorbonne Paris Cité,MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4+ T cells. However, to elicit CD4+-T cells immunity, pAPCs need an additional signal, which can be delivered by Toll-like receptors (TLRs) molecules. TLRs recognize microbial patterns and are critical in initiating immune responses. Proteases, which provide peptide ligands for the MHC class II antigenic presentation pathway, were recently shown to cleave and activate intracellular Toll-like receptors in endosomal compartments. Here, I give an overview on the individual roles of the most well studied proteases in both antigen and TLRs processing.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00299/fullDendritic Cellsprocessingantigen processingProteasesMHC class IIinvariant chain |
| spellingShingle | Bénédicte eManoury Proteases: essential actors in processing antigens and intracellular Toll-like receptors Frontiers in Immunology Dendritic Cells processing antigen processing Proteases MHC class II invariant chain |
| title | Proteases: essential actors in processing antigens and intracellular Toll-like receptors |
| title_full | Proteases: essential actors in processing antigens and intracellular Toll-like receptors |
| title_fullStr | Proteases: essential actors in processing antigens and intracellular Toll-like receptors |
| title_full_unstemmed | Proteases: essential actors in processing antigens and intracellular Toll-like receptors |
| title_short | Proteases: essential actors in processing antigens and intracellular Toll-like receptors |
| title_sort | proteases essential actors in processing antigens and intracellular toll like receptors |
| topic | Dendritic Cells processing antigen processing Proteases MHC class II invariant chain |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00299/full |
| work_keys_str_mv | AT benedicteemanoury proteasesessentialactorsinprocessingantigensandintracellulartolllikereceptors |