Amelioration of obsessive-compulsive disorder by intracellular acidification of cortical neurons with a proton pump inhibitor

Abstract Obsessive-compulsive disorder (OCD) is a highly prevalent neuropsychiatric disorder poorly controlled with pharmacological treatment because of the wide variation in symptom patterns. We analysed real-world data on adverse self-reports and insurance claims to identify a novel therapeutic ta...

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Bibliographic Details
Main Authors: Hikari Hatakama, Nozomi Asaoka, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-024-02731-3