IL-10 partly mediates the ability of MSC-derived extracellular vesicles to attenuate myocardial damage in experimental metabolic renovascular hypertension

IL-10 partly mediates the ability of MSC-derived extracellular vesicles to attenuate myocardial damage in experimental metabolic renovascular hypertension

Extracellular vesicles (EVs) obtain properties of immunomodulation and tissue repair from their parental mesenchymal stem cells (MSCs), and upon delivery may be associated with fewer adverse events. EVs derived from adipose-tissue MSCs restored kidney function by attenuating kidney inflammation in a...

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Bibliographic Details
Main Authors: Yamei Jiang, Siting Hong, Xiangyang Zhu, Lei Zhang, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Weijun Huang, Amir Lerman, Alfonso Eirin, Lilach O. Lerman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
renovascular hypertension
extracellular vesicles
interleukin-10
metabolic syndrome
myocardial damage
mesenchymal stem cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.940093/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.940093/full

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