Gut-derived bacterial toxins impair memory CD4+ T cell mitochondrial function in HIV-1 infection

Gut-derived bacterial toxins impair memory CD4+ T cell mitochondrial function in HIV-1 infection

People living with HIV (PLWH) who are immune nonresponders (INRs) are at greater risk of comorbidity and mortality than are immune responders (IRs) who restore their CD4+ T cell count after antiretroviral therapy (ART). INRs have low CD4+ T cell counts (<350 c/μL), heightened systemic inflamm...

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Bibliographic Details
Main Authors: Brian Ferrari, Amanda Cabral Da Silva, Ken H. Liu, Evgeniya V. Saidakova, Larisa B. Korolevskaya, Konstantin V. Shmagel, Carey Shive, Gabriela Pacheco Sanchez, Mauricio Retuerto, Ashish Arunkumar Sharma, Khader Ghneim, Laura Noel-Romas, Benigno Rodriguez, Mahmoud A. Ghannoum, Peter P. Hunt, Steven G. Deeks, Adam D. Burgener, Dean P. Jones, Mirela A. Dobre, Vincent C. Marconi, Rafick-Pierre Sekaly, Souheil-Antoine Younes
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-05-01
Series:The Journal of Clinical Investigation
Subjects:
AIDS/HIV
Infectious disease
Online Access:https://doi.org/10.1172/JCI149571

Internet

https://doi.org/10.1172/JCI149571

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