SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy

SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy

Electrophilic aldehyde (4-hydroxynonenal; 4-HNE), formed after lipid peroxidation, is a mediator of mitochondrial dysfunction and implicated in both the pathogenesis and the progression of cardiovascular disease. Manganese superoxide dismutase (MnSOD), a nuclear-encoded antioxidant enzyme, catalyzes...

Full description

Bibliographic Details
Main Authors: Sudha Sharma, Susmita Bhattarai, Hosne Ara, Grace Sun, Daret K. St Clair, Md Shenuarin Bhuiyan, Christopher Kevil, Megan N. Watts, Paari Dominic, Takahiko Shimizu, Kevin J. McCarthy, Hong Sun, Manikandan Panchatcharam, Sumitra Miriyala
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Redox Biology
Subjects:
Heart failure
Manganese superoxide dismutase
Superoxide radicals
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309459

Internet

http://www.sciencedirect.com/science/article/pii/S2213231720309459

Similar Items