Aldosterone Excess Induced Mitochondria Decrease and Dysfunction via Mineralocorticoid Receptor and Oxidative Stress In Vitro and In Vivo

Aldosterone Excess Induced Mitochondria Decrease and Dysfunction via Mineralocorticoid Receptor and Oxidative Stress In Vitro and In Vivo

Aldosterone excess plays a major role in the progression of cardiac dysfunction and remodeling in clinical diseases such as primary aldosteronism and heart failure. However, the effect of aldosterone excess on cardiac mitochondria is unclear. In this study, we investigated the effect of aldosterone...

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Bibliographic Details
Main Authors: Cheng-Hsuan Tsai, Chien-Ting Pan, Yi-Yao Chang, Shih-Yuan Peng, Po-Chin Lee, Che-Wei Liao, Chia-Tung Shun, Po-Ting Li, Vin-Cent Wu, Chia-Hung Chou, I-Jung Tsai, Chi-Sheng Hung, Yen-Hung Lin
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomedicines
Subjects:
aldosterone
mitochondrial dysfunction
primary aldosteronism
heart failure
oxidative stress
Online Access:https://www.mdpi.com/2227-9059/9/8/946

Internet

https://www.mdpi.com/2227-9059/9/8/946

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