Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension

Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension

Abstract Skeletal muscle wasting is a clinically remarkable phenotypic feature of pulmonary arterial hypertension (PAH) that increases the risk of mortality. Growth differentiation factor 11 (GDF11), centrally involved in PAH pathogenesis, has an inhibitory effect on skeletal muscle growth in other...

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Bibliographic Details
Main Authors: Guiling Xiang, Kelu Ying, Pan Jiang, Mengping Jia, Yipeng Sun, Shanqun Li, Xiaodan Wu, Shengyu Hao
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Skeletal Muscle
Subjects:
Pulmonary arterial hypertension
GDF11
Skeletal muscle atrophy
STAT3
Online Access:https://doi.org/10.1186/s13395-022-00292-x

Internet

https://doi.org/10.1186/s13395-022-00292-x

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