CD74 promotes the formation of an immunosuppressive tumor microenvironment in triple-negative breast cancer in mice by inducing the expansion of tolerogenic dendritic cells and regulatory B cells.

CD74 promotes the formation of an immunosuppressive tumor microenvironment in triple-negative breast cancer in mice by inducing the expansion of tolerogenic dendritic cells and regulatory B cells.

CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor (MIF). MIF binding to CD74 induces a signaling cascade resulting in the release of its cytosolic intracellular domain (CD74-ICD), which regulates transcription in naïve B and chronic lymphocytic leukemia (CLL) ce...

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Bibliographic Details
Main Authors: Bianca Pellegrino, Keren David, Stav Rabani, Bar Lampert, Thuy Tran, Edward Doherty, Marta Piecychna, Roberto Meza-Romero, Lin Leng, Dov Hershkovitz, Arthur A Vandenbark, Richard Bucala, Shirly Becker-Herman, Idit Shachar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-11-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002905

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https://doi.org/10.1371/journal.pbio.3002905

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