Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes

Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes

Translationally controlled tumor protein (TCTP) regulates several cellular processes, including apoptosis, and is overexpressed in several cancer types. Here, the authors report that high levels of TCTP are associated with poor response to anti-PD-L1 and that TCTP targeting increases the efficacy of...

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Bibliographic Details
Main Authors: Hyo-Jung Lee, Kwon-Ho Song, Se Jin Oh, Suyeon Kim, Eunho Cho, Jungwon Kim, Yun gyu Park, Kyung-Mi Lee, Cassian Yee, Seung-Hwa Song, Suhwan Chang, Jungmin Choi, Sang Taek Jung, Tae Woo Kim
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29611-y

Internet

https://doi.org/10.1038/s41467-022-29611-y

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