Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes
Translationally controlled tumor protein (TCTP) regulates several cellular processes, including apoptosis, and is overexpressed in several cancer types. Here, the authors report that high levels of TCTP are associated with poor response to anti-PD-L1 and that TCTP targeting increases the efficacy of...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29611-y |
| _version_ | 1818147400163786752 |
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| author | Hyo-Jung Lee Kwon-Ho Song Se Jin Oh Suyeon Kim Eunho Cho Jungwon Kim Yun gyu Park Kyung-Mi Lee Cassian Yee Seung-Hwa Song Suhwan Chang Jungmin Choi Sang Taek Jung Tae Woo Kim |
| author_facet | Hyo-Jung Lee Kwon-Ho Song Se Jin Oh Suyeon Kim Eunho Cho Jungwon Kim Yun gyu Park Kyung-Mi Lee Cassian Yee Seung-Hwa Song Suhwan Chang Jungmin Choi Sang Taek Jung Tae Woo Kim |
| author_sort | Hyo-Jung Lee |
| collection | DOAJ |
| description | Translationally controlled tumor protein (TCTP) regulates several cellular processes, including apoptosis, and is overexpressed in several cancer types. Here, the authors report that high levels of TCTP are associated with poor response to anti-PD-L1 and that TCTP targeting increases the efficacy of T cell-mediated anti-tumor therapy. |
| first_indexed | 2024-12-11T12:34:38Z |
| format | Article |
| id | doaj.art-2e832e4f516d4e8ba956b812b9171d28 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-11T12:34:38Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2e832e4f516d4e8ba956b812b9171d282022-12-22T01:07:09ZengNature PortfolioNature Communications2041-17232022-04-0113111710.1038/s41467-022-29611-yTargeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypesHyo-Jung Lee0Kwon-Ho Song1Se Jin Oh2Suyeon Kim3Eunho Cho4Jungwon Kim5Yun gyu Park6Kyung-Mi Lee7Cassian Yee8Seung-Hwa Song9Suhwan Chang10Jungmin Choi11Sang Taek Jung12Tae Woo Kim13Department of Biochemistry and Molecular Biology, Korea university College of MedicineResearch Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of MedicineDepartment of Biochemistry and Molecular Biology, Korea university College of MedicineDepartment of Biochemistry and Molecular Biology, Korea university College of MedicineDepartment of Biochemistry and Molecular Biology, Korea university College of MedicineDepartment of Biochemistry and Molecular Biology, Korea university College of MedicineDepartment of Biochemistry and Molecular Biology, Korea university College of MedicineDepartment of Biochemistry and Molecular Biology, Korea university College of MedicineDepartment of Melanoma Medical Oncology and Immunology, U.T. MD Anderson Cancer CenterDepartment of Biochemistry and Molecular Biology, Korea university College of MedicineDepartment of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical CenterDepartment of Biomedical Science, Korea university College of MedicineDepartment of Biomedical Science, Korea university College of MedicineDepartment of Biochemistry and Molecular Biology, Korea university College of MedicineTranslationally controlled tumor protein (TCTP) regulates several cellular processes, including apoptosis, and is overexpressed in several cancer types. Here, the authors report that high levels of TCTP are associated with poor response to anti-PD-L1 and that TCTP targeting increases the efficacy of T cell-mediated anti-tumor therapy.https://doi.org/10.1038/s41467-022-29611-y |
| spellingShingle | Hyo-Jung Lee Kwon-Ho Song Se Jin Oh Suyeon Kim Eunho Cho Jungwon Kim Yun gyu Park Kyung-Mi Lee Cassian Yee Seung-Hwa Song Suhwan Chang Jungmin Choi Sang Taek Jung Tae Woo Kim Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes Nature Communications |
| title | Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes |
| title_full | Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes |
| title_fullStr | Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes |
| title_full_unstemmed | Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes |
| title_short | Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes |
| title_sort | targeting tctp sensitizes tumor to t cell mediated therapy by reversing immune refractory phenotypes |
| url | https://doi.org/10.1038/s41467-022-29611-y |
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