Doxorubicin Caused Apoptosis of Mesenchymal Stem Cells via p38, JNK and p53 Pathway

Doxorubicin Caused Apoptosis of Mesenchymal Stem Cells via p38, JNK and p53 Pathway

Background/Aims: Doxorubicin is a widely used chemotherapeutic agent, but its clinical use is restricted because of a high risk of cardiotoxicity. Bone marrow-derived mesenchymal stem cells (BMSCs) may repair ischaemically damaged myocardium through transdifferentiation and paracrine action. The aim...

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Bibliographic Details
Main Authors: Fan Yang, Hongyang Chen, Yanju Liu, Kun Yin, Yang Wang, Xingda Li, Guohui Wang, Siyue Wang, Xueying Tan, Chaoqian Xu, Yanjie Lu, Benzhi Cai
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Bone marrow-derived mesenchymal stem cells
p53
ROS
Doxorubicin
Apoptosis
Online Access:http://www.karger.com/Article/FullText/354507

Internet

http://www.karger.com/Article/FullText/354507

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