Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration

Abstract Background Limited supply of certain nutrients and deregulation of nucleus pulposus (NP) plays a key role in the pathogenesis of intervertebral disc degeneration (IVDD). However, whether nutrient deprivation-induced cell death, particularly disulfidptosis, contributes to the depletion of NP...

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Bibliographic Details
Main Authors: Shaobo Wu, Jin Wang, Minglin Wang, Kaisheng Zhou, Dageng Huang, Yilei Zhang, Haihong Zhang
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Biology Direct
Subjects:
Online Access:https://doi.org/10.1186/s13062-024-00528-4