Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses

Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses

T follicular helper (Tfh) cells play critical roles for germinal center responses and effective humoral immunity. We report here that mTOR in CD4 T cells is essential for Tfh differentiation. In Mtorf/f-Cd4Cre mice, both constitutive and inducible Tfh differentiation is severely impaired, leading to...

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Bibliographic Details
Main Authors: Jialong Yang, Xingguang Lin, Yun Pan, Jinli Wang, Pengcheng Chen, Hongxiang Huang, Hai-Hui Xue, Jimin Gao, Xiao-Ping Zhong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-09-01
Series:eLife
Subjects:
T Follicular Helper Cell
germinal center B cell
signal transduction
mTOR
lymphocyte subsets
Online Access:https://elifesciences.org/articles/17936

Internet

https://elifesciences.org/articles/17936

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