Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice.

Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice.

High-level fetal (γ) globin expression ameliorates clinical severity of the beta (β) hemoglobinopathies, and safe, orally-bioavailable γ-globin inducing agents would benefit many patients. We adapted a LCR-γ-globin promoter-GFP reporter assay to a high-throughput robotic system to evaluate five dive...

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Bibliographic Details
Main Authors: Michael S Boosalis, Jose I Sangerman, Gary L White, Roman F Wolf, Ling Shen, Yan Dai, Emily White, Levi H Makala, Biaoru Li, Betty S Pace, Mehdi Nouraie, Douglas V Faller, Susan P Perrine
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4694699?pdf=render

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http://europepmc.org/articles/PMC4694699?pdf=render

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