Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition

Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition

Summary: Combined inhibition of oxidative phosphorylation (OXPHOS) and glycolysis has been shown to activate a PP2A-dependent signaling pathway, leading to tumor cell death. Here, we analyze highly selective mitochondrial complex I or III inhibitors in vitro and in vivo to elucidate the molecular me...

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Bibliographic Details
Main Authors: Riccardo Cazzoli, Francesco Romeo, Isabella Pallavicini, Sebastiano Peri, Mauro Romanenghi, Juan Alberto Pérez-Valencia, Eman Hagag, Filippo Ferrucci, Mohamed Elgendy, Orazio Vittorio, Salvatore Pece, Marco Foiani, Jukka Westermarck, Saverio Minucci
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723006277

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http://www.sciencedirect.com/science/article/pii/S2211124723006277

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