A human 3D immune competent full-thickness skin model mimicking dermal dendritic cell activation

A human 3D immune competent full-thickness skin model mimicking dermal dendritic cell activation

We have integrated dermal dendritic cell surrogates originally generated from the cell line THP-1 as central mediators of the immune reaction in a human full-thickness skin model. Accordingly, sensitizer treatment of THP-1-derived CD14-, CD11c+ immature dendritic cells (iDCs) resulted in the phospho...

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Bibliographic Details
Main Authors: Johanna Maria Hölken, Katja Friedrich, Marion Merkel, Nelli Blasius, Ursula Engels, Timo Buhl, Karsten Rüdiger Mewes, Lars Vierkotten, Nicole Elisabeth Teusch
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
full-thickness skin model
dermal dendritic cell
nickel
DNCB
CD86
p38 MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276151/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276151/full

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