Grb2 dimer interacts with Coumarin through SH2 domains: A combined experimental and molecular modeling study

Grb2 dimer interacts with Coumarin through SH2 domains: A combined experimental and molecular modeling study

Grb2 is an important regulator of normal vs. oncogenic cell signaling transduction. It plays a pivotal role on kinase-mediated signaling transduction by linking Receptor Tyrosine kinases to Ras/MAPK pathway which is known to bring oncogenic outcome. Coumarins are phenolic molecules found in several...

Full description

Bibliographic Details
Main Authors: Karoline Sanches, Raphael Vinicius Rodrigues Dias, Paulo Henrique da Silva, Marcelo Andrés Fossey, Ícaro Putinhon Caruso, Fátima Pereira de Souza, Leandro Cristante de Oliveira, Fernando Alves de Melo
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Heliyon
Subjects:
Biochemistry
Molecular biology
Biophysics
Biophysical chemistry
Spectroscopy
Biomolecules
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844019365284

Internet

http://www.sciencedirect.com/science/article/pii/S2405844019365284

Similar Items