6-Bromoisatin Found in Muricid Mollusc Extracts Inhibits Colon Cancer Cell Proliferation and Induces Apoptosis, Preventing Early Stage Tumor Formation in a Colorectal Cancer Rodent Model

6-Bromoisatin Found in Muricid Mollusc Extracts Inhibits Colon Cancer Cell Proliferation and Induces Apoptosis, Preventing Early Stage Tumor Formation in a Colorectal Cancer Rodent Model

Muricid molluscs are a natural source of brominated isatin with anticancer activity. The aim of this study was to examine the safety and efficacy of synthetic 6-bromoisatin for reducing the risk of early stage colorectal tumor formation. The purity of 6-bromoisatin was confirmed by 1H NMR spectrosc...

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Bibliographic Details
Main Authors: Babak Esmaeelian, Catherine A. Abbott, Richard K. Le Leu, Kirsten Benkendorff
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Marine Drugs
Subjects:
apoptosis
azoxymethane
bioactive natural product
colorectal cancer
isatin
in vivo model
marine mollusc
Online Access:http://www.mdpi.com/1660-3397/12/1/17

Internet

http://www.mdpi.com/1660-3397/12/1/17

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