IL-6/STAT3 signaling in tumor cells restricts the expression of frameshift-derived neoantigens by SMG1 induction

IL-6/STAT3 signaling in tumor cells restricts the expression of frameshift-derived neoantigens by SMG1 induction

Abstract Background The quality and quantity of tumor neoantigens derived from tumor mutations determines the fate of the immune response in cancer. Frameshift mutations elicit better tumor neoantigens, especially when they are not targeted by nonsense-mediated mRNA decay (NMD). For tumor progressio...

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Bibliographic Details
Main Authors: Daniel Meraviglia-Crivelli, Helena Villanueva, Angelina Zheleva, María Villalba-Esparza, Beatriz Moreno, Ashwathi Puravankara Menon, Alfonso Calvo, Javier Cebollero, Martin Barainka, Igor Ruiz de los Mozos, Carlos Huesa-Berral, Fernando Pastor
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Molecular Cancer
Subjects:
Tumor immunity
Neoantigens
Cancer immunotherapy
Immunoediting
NMD
Online Access:https://doi.org/10.1186/s12943-022-01679-6

Internet

https://doi.org/10.1186/s12943-022-01679-6

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