Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice

Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice

Objective: Mitochondrial disorders are often characterized by muscle weakness and fatigue. Null mutations in the heart-muscle adenine nucleotide translocator isoform 1 (ANT1) of both humans and mice cause cardiomyopathy and myopathy associated with exercise intolerance and muscle weakness. Here we d...

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Bibliographic Details
Main Authors: Patrick M. Schaefer, Jessica Huang, Arrienne Butic, Caroline Perry, Tal Yardeni, Wendy Tan, Ryan Morrow, Joseph A. Baur, Douglas C. Wallace
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Molecular Metabolism
Subjects:
Mitochondrial disorder
Exercise
Nicotinamide riboside
NAD+/NADH
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001296

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http://www.sciencedirect.com/science/article/pii/S2212877822001296

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