Lipid Nanoparticle-Mediated Lymphatic Delivery of Immunostimulatory Nucleic Acids

Lipid Nanoparticle-Mediated Lymphatic Delivery of Immunostimulatory Nucleic Acids

Lymphatic delivery of a vaccine can be achieved using a dendritic cell (DC)-targeted delivery system that can cause DC to migrate to lymph nodes upon activation by an adjuvant. Here, we designed a mannose-modified cationic lipid nanoparticle (M-NP) to deliver the nucleic acid adjuvant, polyinosinic:...

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Bibliographic Details
Main Authors: Dongyoon Kim, Yina Wu, Gayong Shim, Yu-Kyoung Oh
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
nucleic acid adjuvant
lipid nanoparticle
lymphatic delivery
dendritic cell-targeted delivery
Online Access:https://www.mdpi.com/1999-4923/13/4/490

Internet

https://www.mdpi.com/1999-4923/13/4/490

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