Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways

Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways

Abstract Background Breast cancer currently is the most frequently diagnosed neoplasm and the leading cause of death from cancer in women worldwide, which is mainly due to metastatic disease. Increasing our understanding of the molecular mechanisms leading to metastasis might thus improve the pharma...

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Bibliographic Details
Main Authors: José Esparza-López, Juan Francisco Alvarado-Muñoz, Elizabeth Escobar-Arriaga, Alfredo Ulloa-Aguirre, María de Jesús Ibarra-Sánchez
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Cancer
Subjects:
Breast Cancer
Epithelial-mesenchymal transition
Metformin
STAT3
NF-κB
AMPK
Online Access:http://link.springer.com/article/10.1186/s12885-019-5945-1

Internet

http://link.springer.com/article/10.1186/s12885-019-5945-1

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